10 Unique Places To Stay In South Carolina That Offer Memorable Experiences

As local travel experts, we know what travelers are looking for when it comes to finding the perfect accommodations for their next trip. To compile our lists, we scour the internet to find properties with excellent ratings and reviews, desirable amenities, nearby attractions, and that something special that makes a destination worthy of traveling for.

Whether your idea of a vacation getaway is the luxurious boutique hotel experience you’d find at Zero George Street in Charleston, or you’d go gaga over a treehouse rental in the woods near Congaree National Park, there are numerous fun and exciting rentals to choose from in the Palmetto State. To get your creative vacation planning senses all a-tingle, here are some of the most unique places to stay in South Carolina.

Treehouse Rentals in South Carolina

A vacation in a treehouse is one of the most unique experiences you can have. There is nothing more romantic or adventurous than a cozy treehouse rental surrounded by nature. Here is a couple we think you’ll really enjoy. They are such fun places to stay in South Carolina!

Tiny Home Rentals in South Carolina

A stay in a tiny house is such a delightful way to spend time with someone you love. And these two tiny home rentals are special each in their own unique way. We hope they tickle your fancy and get you looking forward to a unique getaway.

Farm Houses for Rent in South Carolina

If your idea of the perfect vacation includes a few donkeys, horses, chickens, and an adorable potbellied pig, we think you’ll get a kick out of these two farmhouse rentals in SC.

Log Cabins for Rent in South Carolina

South Carolina has some of the most beautiful natural areas in the country. And the most immersive experience you’ll find is in an authentic log cabin. If you love the outdoors as much as we do, you’ll feel right at home in one of these cool log cabin rentals.

Luxury Beach House Rentals in South Carolina

South Carolina offers some of the most incredible beach houses in the nation. Whether you find a dream home on Sullivan’s Island or a Myrtle Beach mansion, there is nothing like a beach vacation where you can step out your back door and walk right into the ocean.

South Carolina has such wonderful vacation rentals available, from cozy treehouse rentals in Upstate SC to quiet suburban tiny homes in Mount Pleasant, or even large luxurious mansions on the beach. If you are looking for unique places to stay in South Carolina we hope we’ve given you some inspirational ideas to get you started. Where are your favorite places to stay in South Carolina? Share some of your favorite finds with a comment.

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Unique Places to Stay in South Carolina

  1. Treehouse by the Sea

  2. Branches Up Tree House

  3. The River Birch

  4. Indigo Escape

  5. The Bluffton Farmhouse

  6. Springwater Farm

  7. Historic Log Cabin

  8. Secluded Log Cabin

  9. Low Tide Too

  10. Kiawah Beach Mansion

The OIYS Visitor Center

More Unique rentals in South Carolina

March 29, 2023

What are the best unique hotels in South Carolina?

With so many iconic boutique hotels in South Carolina like the Wentworth Mansion or the French Quarter Inn, you'll have no trouble finding unique places to stay on your next SC vacation. Here are some of the best unique hotels in South Carolina if you need a little bit more inspiration:

  • Battery Carriage House, Charleston, SC: Looking for a little adventure? This inn was built in 1843 and is the top-rated inn in Charleston, SC. Some say it is also the most haunted inn in South Carolina. It's surely a place where many adventures await. Enjoy the beautiful Waterfront Park overlooking Charleston Harbor in a town that is filled with Southern charm.
  • Hotel Florence, Florence, SC: This hotel is located in the heart of downtown Florence. Close to boutique shopping, fine dining, and offering luxurious elegance at your fingertips. Check in to this historic redbrick boutique hotel minutes away from the Francis Marion University Performing Arts Center for an evening of exquisite artistic entertainment.
  • The Pelican Inn, Pawleys Island, SC: Private beach access, rope hammocks, and a room in an inn that was built in the 1840s. What more could you possibly ask for? The laid-back feel of Pawleys Island is just begging you to take off your shoes, walk the sandy beaches, and then fall asleep reading a good book swinging in a hammock as the sun sets and ocean breezes soothe your soul.
  • The Charleston Place, Charleston, SC: The epitome of luxury and class awaits you at this historic downtown luxury hotel. This iconic hotel is within walking distance of everything that is wonderful about Charleston. Fine dining, luxury spas, shopping along King Street, and entertainment galore. Or simply spend an evening with a drink on the rooftop deck with a dip in the saltwater swimming pool.


Where are the most unique getaways in South Carolina?

South Carolina has some pretty interesting rentals, inns, bed and breakfasts, and places to stay. Whether your idea of a unique stay is a caboose getaway in Columbia, or you prefer a Civil War-era historic inn, here are some of the most unique getaways in South Carolina:

  • Cuthbert House Inn, Beaufort, SC: Become surrounded by the beauty that only the Lowcountry can give you. This gorgeous 18th-century mansion has been giving guests special treatment for over 200 years. It's like stepping back in time to enjoy the good life on Port Royal Island with only the finest of amenities, luxurious linens, and enchanting guest rooms that make you feel like royalty.
  • King Charles Inn, Charleston, SC: This inn used to be known as The Pavilion Hotel a long time ago and is famous for the fact that Edgar Allen Poe stayed here. Today, it is a luxurious inn with beautiful suites. It's located in the heart of downtown Charleston.
  • Bush River Farm Bed & Breakfast, Clinton, SC: If you want to go on an international vacation, but your budget is not up for it we have a place for you! The Bush River Farm Bed and Breakfast is like visiting Ireland right here in South Carolina. This charming old inn takes you on an adventure with rolling hills of green on a working organic farm with beautiful gardens, winery tours, and delicious home-cooked breakfasts.