When you are searching for beautiful waterfalls and local wineries, South Carolina is the ultimate place to go. However, it can feel a little overwhelming when you want to see some of the best that the Palmetto State has to offer. That’s where we come in. We have created an epic multi-day road trip in South Carolina to some of the best waterfalls and local wineries in the state. Get ready for an adventure because this is a trip you are going to remember!

The itinerary takes us approximately 480 miles around the state. You will want to plan for at least 10 hours of drive time and many more hours to explore and enjoy all of the stops along the way. Fortunately, you won’t need to rush through this trip because we have located several Best Western hotels in South Carolina along the way. This allows you to get an early start or simply relax and recuperate before you continue on your way.

Related Stories

This Rural Road Trip Will Lead You To Some Of The Best Countryside Hidden Gems In South Carolina

This Rural Road Trip Will Lead You To Some Of The Best Countryside Hidden Gems In South Carolina

It's Worth It To Drive Across South Carolina Just For The Burgers At Higher Ground Char House

It's Worth It To Drive Across South Carolina Just For The Burgers At Higher Ground Char House

It's Worth It To Drive Across South Carolina Just For The French Toast At Croissants Bistro And Bakery

It's Worth It To Drive Across South Carolina Just For The French Toast At Croissants Bistro And Bakery

What do you think about this waterfall and wineries road trip in South Carolina? Are there any additional stops you’d make to the route? If so, let us know in the comments! And, don’t forget to book a stay at the closest Best Western property during all of your upcoming adventures in South Carolina!