Route 66 might be the most famous road in America, and it runs straight through Missouri. Yep, for more than 300 glorious miles, the Mother Road meanders through small towns and past world-famous attractions. Today’s road trip will take you to some of the most charming Route 66 towns in Missouri (starting in one of our big cities, too). Each destination is brimming with things to see and to do, so you can do as much or as little as you want, depending on your timeframe.

Here are the Google Map directions for this road trip that spans 304 miles and the length of Route 66 in Missouri. Add or remove stops to meet your interests, needs, and timeframe.

What are your favorite Route 66 towns in Missouri? Let us know in the comments! Up for more exploring? Here are 11 iconic stops along Route 66 in Missouri.

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