Life can get pretty rough sometimes. On those tough days, something as simple as a smile and a friendly greeting can really lift our spirits. Sometimes, however, we just need to get away – for a day, a weekend, or longer. When you need a pick-me-up, plan a visit to the friendliest town in Missouri.

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Do you agree that Maryville is the friendliest town in Missouri? You might also want to plan a visit to these 10 small towns in rural Missouri that are downright delightful.

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