Most people don’t realize “The Loneliest Road In America” passes right through Ohio. Stretching across 11 states and showcasing some of America’s best scenery, US Route 50 is a 3,200-mile road everyone in America has likely traveled at least once. It winds its way through the southern portion of Ohio, showing off some of the state’s best rural scenery and small towns. If you’ve yet to travel this road, it’s the perfect route to take on a lazy Sunday or anytime you just need a good, long drive. It’s really one of the best scenic drives in Ohio. Let’s take a look:

You'll experience a mix of small town Ohio and rural scenery along this route. (Several parts of the Ohio portion will also turn into freeway stretches.)
Bill Herndon/Flickr
Pictured is Route 50 near Albany, Ohio.
The route passes through the Cincinnati area, Ohio University and smaller Ohio cities as well, so you'll get to see a little bit of everything.
Screenshot via Google Maps
Near Cincinnati, a small stretch of the route runs along The Ohio River Scenic Byway, which is a gorgeous route that features great views of the river.
You'll likely notice several historic markers as you pass through small towns and villages, as Route 50 follows the footsteps of pioneers.
Doug Kerr/Flickr
Pictured is the lovely village of Mariemont in Hamilton County.

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The rural scenery along this route is what makes a Route 50 journey so special. You'll see several Mail Pouch and Ohio Bicentennial barns.
Mike/Flickr
Pictured is a Mail Pouch barn along Route 50 in Athens County.
You'll also pass through the small city of Chillicothe (pictured), which was actually Ohio's first capital.
Doug Kerr/Flickr
If you have time for a stop, you'll want to check out the nearby Mound City, which features the largest collection of Hopewell culture burial mounds in eastern North America.
"The Loneliest Road in Ohio" not only features scenic views of the state; it also features 220 miles of American and Ohio history you just can't experience inside a museum.
Doug Kerr/Flickr
It's a drive everyone in the state needs to take at least once. <3

Have you ever traveled this road before? What is your favorite road to travel in Ohio? Share your photos and experiences with us in the comments below!

For more of the best scenic drives in Ohio, check out our previous article: These 9 Beautiful Byways In Ohio Are Perfect For A Scenic Drive.

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More to Explore

best scenic drives in Ohio

Sarah | August 04, 2021

What are some of the best scenic drives in Ohio?

In addition to the delightful drive outlined above, you'll want to check out these 10 country backroads. Along these scenic routes, you'll get a real sense of the beauty and diversity of the Buckeye State, with its idyllic farmland, rolling hills (especially in the southeastern side of the state, which is Appalachian territory), and glorious river towns. In the autumn, Ohio becomes especially winsome, as the fall foliage colors the countryside rich reds, bold oranges, and vibrant golds and yellows. Take these seven fall foliage drives, and you're sure to be enchanted by the beauty of the Buckeye State!

What are some fun attractions along US State Route 50 in Ohio?

Contrary to its nickname, US 50 is actually a delightful route that not only passes through some seriously scenic areas, but also some fun attractions! The scenic drive runs parallel to the Little Miami River in Milford and Terrace Park, and there are several canoe outfitters where you can enjoy an afternoon on the water. Fifty West Brewing Company is a fun local brewery to stop at, especially after canoeing! And then there's Mariemont, one of the most adorable small towns in Ohio, and between its historic eateries, old-school theatre, and charming downtown, you'll find lots to do as you drive down US Route 50!

What are some fun road trips in Ohio?

Ohio is a state that was made for road trips, as its size allows adventurers to journey across the state -- and back! -- in a day! We love a good road trip at Only In Ohio, and this list details 10 of our absolute must-do adventures. From waterfall chasing and ghost hunting, to discovering small towns and hidden gems, each and every one of these road trips will lead you on an unforgettable adventure in Ohio.

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Featured Addresses
U.S. 50, US-50, Cincinnati, OH, USA