Shortly after President Thomas Jefferson signed the deal to purchase the Louisiana Territory from the French in 1803, he commissioned Mariwether Lewis and William Clark to explore the newly acquired land. Just a year later, the two began their expedition exploring the wild west. They followed the Missouri River and the entire trip took a little over 2 years but the discoveries made helped to establish the America that we know today. Follow in the footsteps of these great explorers on an epic road trip across Missouri to some of the most historic places on the state map.

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Have you been to any of the historical sites in Missouri where Lewis and Clark first explored? If you take this road trip, tell us about it in the comments below!

Looking for a place to stay after driving across the state? If you end on the west side of Missouri be sure to check out this stunning stone mansion that’s now a relaxing B&B. If you end this trip on the east side of the state, check out this amazing glampsite for some high-quality camping.

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